Acne Treatment Without Overpaying: Adapalene Over the Counter vs Prescription, US Costs and Buying Online Safely

In the US you can treat a lot of acne without a prescription. Adapalene 0.1% gel (sold as Differin Gel) has been over the counter since the FDA approved the switch on 8 July 2016, and since 22 May 2026 the adapalene 0.1% and benzoyl peroxide 2.5% combination has also been sold over the counter as Differin Epiduo. Benzoyl peroxide and salicylic acid have long been available off the shelf. Stronger retinoids, topical antibiotics, dapsone gel, oral antibiotics, spironolactone and isotretinoin still need a prescriber.

This guide sets out what you can buy without a prescription, what still needs one and how US patients usually get it, and what each common acne medicine costs US pharmacies in the federal NADAC price survey for the week of 28 October 2026. It then covers the iPLEDGE rules for isotretinoin, what the FDA says about importing medicine and spotting an unsafe online pharmacy, and what SafeRxPills sells. We sell acne medicines made in India, so we have a commercial interest; every figure here comes from an FDA label, an FDA page or database, or the CMS price file listed under Sources, and our own prices come from our product listings.

The short answer

Start with what is on the shelf if your acne is mild: adapalene 0.1% gel, adapalene 0.1% with benzoyl peroxide 2.5%, benzoyl peroxide 2.5% to 10%, or salicylic acid 0.5% to 2%. If that has not worked after the time the label gives (up to 3 months of once daily use for adapalene), or your acne is inflamed, scarring or widespread, see a prescriber in person or by telehealth. When you get a prescription, ask for the generic. In the October 2026 NADAC data, 30 g of generic clindamycin 1% gel cost US pharmacies $4.25 and 30 g of generic adapalene 0.3% with benzoyl peroxide 2.5% cost $19.42, while the brand of that same combination, Epiduo Forte, cost $449.02 for 30 g. Isotretinoin is different: in the US it is only dispensed through the iPLEDGE program, and there is no legal shortcut around it. For every acne option by severity, see our acne treatment hub.

What you can buy without a prescription in the US

The FDA lets two kinds of acne products be sold over the counter (OTC). The first kind follows the FDA's OTC acne monograph (M006), which lists the active ingredients and strengths any maker can use without an individual approval. The second kind is a specific product the FDA has switched from prescription to OTC through its own application, which is how adapalene arrived.

Active ingredient	OTC strength allowed	How it got there
Benzoyl peroxide	2.5% to 10%	OTC monograph M006
Salicylic acid	0.5% to 2%	OTC monograph M006
Sulfur	3% to 10% (3% to 8% with resorcinol)	OTC monograph M006
Adapalene	0.1% gel (Differin Gel)	Rx-to-OTC switch, NDA 020380, 8 July 2016
Adapalene with benzoyl peroxide	0.1% / 2.5% gel (Differin Epiduo)	Partial Rx-to-OTC switch, NDA 220736, 22 May 2026

The monograph covers only the ingredients and strengths listed. Adapalene 0.3% gel, adapalene 0.1% cream and Epiduo Forte (adapalene 0.3% with benzoyl peroxide 2.5%) are still listed as prescription products in Drugs@FDA.

Adapalene over the counter: what changed in 2016 and 2026

Adapalene was first approved for prescription use in 1996. On 8 July 2016 the FDA approved Galderma's supplemental application to sell Differin Gel 0.1% over the counter "for the treatment of acne in adults and children ages 12 years and older", in tubes of 2 g, 15 g and 45 g. Before that decision, an FDA advisory committee had voted unanimously, in April 2016, that the safety of adapalene gel 0.1% for OTC use had been adequately shown.

The second change came in 2026. Drugs@FDA records NDA 220736, Differin Epiduo gel (adapalene 0.1% and benzoyl peroxide 2.5%), approved on 22 May 2026 as a partial Rx-to-OTC switch, in 15 g, 30 g and 45 g sizes. The original prescription Epiduo application is now listed as discontinued. The stronger Epiduo Forte stays prescription only.

What did not change: adapalene 0.3% gel and the 0.1% cream still need a prescription, and so do tretinoin and tazarotene. For how adapalene and tretinoin compare in trials, see our adapalene vs tretinoin guide.

How the OTC labels say to use adapalene

The Drug Facts labels for Differin Gel and Differin Epiduo give the same core directions for adults and children 12 years and older: use once daily, clean the skin gently and pat it dry, and cover the whole affected area with a thin layer (for acne on the face, the entire face). The labels state that applying more than directed will not give faster or better results but may worsen irritation.

• Expect a slow start. Both labels say acne may appear to worsen in the early weeks, and that it may take up to 3 months of once daily use to see results.
• Do not use on damaged skin (cuts, abrasions, eczema, sunburn) or if you are allergic to adapalene or any ingredient. The Epiduo label adds: do not use if you have very sensitive skin or are sensitive to benzoyl peroxide.
• Sun and waxing. Limit sun exposure including tanning beds, use sunscreen outdoors, and do not wax treated areas.
• Bleaching. The Epiduo label warns it may bleach hair and dyed fabrics, which is a benzoyl peroxide effect.
• Pregnancy. Both labels say to stop use and ask a doctor if you become pregnant or plan to. Both labels also say to ask a doctor before use if pregnant or breastfeeding.
• Children under 12. Differin Gel says ask a doctor; Differin Epiduo says do not use.

What still needs a prescription

Everything below is listed as a prescription product in the US. These are the medicines a prescriber usually reaches for when OTC products are not enough. Which cream works best by the trial evidence is covered in our prescription skin care medicine guide; this page sticks to access and cost.

Medicine	Form	What the US label says it is for
Tretinoin (Retin-A and generics)	Cream, gel	Topical treatment of acne vulgaris
Adapalene 0.3%, adapalene 0.1% cream	Gel, cream	Acne vulgaris
Tazarotene 0.1% (Tazorac and generics)	Cream, gel	Acne vulgaris (also plaque psoriasis)
Clindamycin 1% (Cleocin T and generics)	Gel, solution, lotion	Acne vulgaris
Clindamycin with benzoyl peroxide	Gel	Acne vulgaris
Dapsone 5% and 7.5% (Aczone and generics)	Gel	Acne vulgaris (7.5%: age 9 and older)
Azelaic acid 20% (Azelex)	Cream	Mild to moderate inflammatory acne vulgaris
Doxycycline, minocycline	Capsules, tablets	"In severe acne... may be useful adjunctive therapy"
Isotretinoin	Capsules	Severe recalcitrant nodular acne, age 12 and older, via iPLEDGE
Spironolactone	Tablets	Not labeled for acne (used off label)

One trap: generic azelaic acid 15% gel, the one that appears in the price survey, is labeled in the US for the papules and pustules of rosacea, not for acne. The acne-labeled product is the 20% cream. Our azelaic acid cream guide explains the difference. For clindamycin gel specifically, see topical antibiotics for acne.

How US patients get an acne prescription

There are two common routes, and both end with a prescription sent to a pharmacy of your choice.

• In person. A primary care clinician can prescribe most topical and oral acne medicines. A dermatologist is the usual route for severe, scarring or treatment-resistant acne, and for isotretinoin, which can only be prescribed by a prescriber registered with iPLEDGE.
• Telehealth. Many prescribers assess acne by video or by reviewing photos and a questionnaire, where their state's rules allow. The prescription is then sent electronically to a US pharmacy or a mail-order pharmacy. Fees and what is included differ by service, so ask what you will pay for the visit and for the medicine before you start.

Isotretinoin has an extra in-person step. The FDA's iPLEDGE page states that all pregnancy tests before starting treatment must be done in a medical setting, even though prescribers may now allow home tests during and after treatment. A telehealth service can manage much of an isotretinoin course, but not that first step.

What NADAC is, and why it is not your shelf price

NADAC stands for National Average Drug Acquisition Cost. CMS runs a monthly nationwide survey of the invoice prices that retail community pharmacies, both chains and independents, pay for covered outpatient drugs, and publishes the averages weekly. State Medicaid programs can use it to set what they reimburse.

That makes NADAC useful for one thing: comparing what one medicine costs against another at the wholesale level, on the same day, with no marketing markup or coupon in the way. It is not the price you pay. Your price at the counter adds the pharmacy's margin and dispensing fee, and depends on your insurance, deductible, any discount program and the pharmacy you use. Read the figures below as "what the pharmacy paid", and expect to pay more.

Two more points. NADAC lists drugs per gram, per milliliter or per tablet, so the charts below multiply by a fixed amount (30 g or 30 units) to make the numbers readable. And NADAC covers some OTC products: in this week's file every adapalene 0.1% gel and benzoyl peroxide gel row is flagged as OTC, while the adapalene 0.1% with benzoyl peroxide 2.5% rows are prescription generics.

What topical acne medicines cost US pharmacies

These are the median NADAC figures for the latest week available, 28 October 2026, for generic versions of each product. The "per 30 g" column is simple multiplication; actual tubes and pumps come in different sizes.

Generic product	NADAC per gram	Per 30 g	US status
Clindamycin 1% gel	$0.14183	$4.25	Prescription
Benzoyl peroxide 2.5% gel	$0.20673	$6.20	OTC
Benzoyl peroxide 5% gel	$0.21779	$6.53	OTC
Benzoyl peroxide 10% gel	$0.22693	$6.81	OTC
Adapalene 0.1% / benzoyl peroxide 2.5% gel	$0.38730	$11.62	Prescription generic (the Differin Epiduo version is OTC)
Adapalene 0.1% gel	$0.43842	$13.15	OTC since 2016
Adapalene 0.3% gel	$0.49934	$14.98	Prescription
Tretinoin 0.025% cream	$0.50808	$15.24	Prescription
Dapsone 5% gel	$0.58278	$17.48	Prescription
Clindamycin 1% / benzoyl peroxide 5% gel	$0.63315	$18.99	Prescription
Adapalene 0.3% / benzoyl peroxide 2.5% gel	$0.64744	$19.42	Prescription
Dapsone 7.5% gel pump	$0.76991	$23.10	Prescription
Tretinoin 0.1% cream	$0.87201	$26.16	Prescription
Tretinoin 0.05% cream	$1.40414	$42.12	Prescription
Tazarotene 0.1% cream	$1.90560	$57.17	Prescription

Three things stand out. Generic clindamycin gel is the cheapest prescription topical in the list, about one thirteenth of the cost of tazarotene cream per gram. The tretinoin creams do not rise in price with strength: in this week's data the 0.05% cream cost more per gram than the 0.1% cream. And form matters as much as molecule: generic tazarotene 0.1% gel cost $6.03116 per gram ($180.93 per 30 g), more than three times the cream, and the tretinoin gels ($2.60844 per gram for 0.025%) cost several times the creams. For tretinoin prices in more detail, see buy tretinoin online.

What oral acne medicines cost US pharmacies

Oral medicines are priced per capsule or tablet. The table shows the NADAC for one unit and for 30 units. Thirty units is not a dose: your prescriber sets the dose and how long you take it.

Generic product	NADAC per unit	Per 30 units
Spironolactone 50 mg tablet	$0.08328	$2.50
Doxycycline hyclate 100 mg capsule	$0.10794	$3.24
Doxycycline hyclate 100 mg tablet	$0.11995	$3.60
Minocycline 100 mg capsule	$0.33466	$10.04
Minocycline 100 mg tablet	$0.64629	$19.39
Isotretinoin 20 mg capsule (Claravis, Amnesteem, Zenatane)	$1.93429	$58.03
Isotretinoin 20 mg capsule (sold under the generic name)	$4.18071	$125.42

Doxycycline and minocycline are cheap at the pharmacy level, but the US labels describe them only as "useful adjunctive therapy" in severe acne, and modified-release versions cost much more: doxycycline hyclate delayed-release 100 mg tablets were $2.16424 each in the same week. Our doxycycline for acne guide covers dose and duration, and doxycycline vs minocycline compares the two.

Brand vs generic: where the gap is biggest

Brand acne products can cost many times their generic equivalents. NADAC had current brand entries for only a few acne products this year; Aczone, Retin-A, Tazorac and Solodyn had no 2026 NADAC rows, so they are left out rather than estimated.

Product	Brand NADAC per gram	Generic NADAC per gram	Brand per 30 g	Generic per 30 g
Adapalene 0.3% / benzoyl peroxide 2.5% (Epiduo Forte gel pump; the generics priced are also 45 g pumps)	$14.96720	$0.64744	$449.02	$19.42
Adapalene 0.1% cream (Differin)	$11.27062 (last reported 13 May 2026)	$2.72225	$338.12	$81.67

Epiduo Forte cost pharmacies about 23 times the generic per gram, and Differin cream about 4 times. If a prescription is written for a brand name, ask the prescriber or pharmacist whether a generic of the same strength and form is available. Note the form: the generic adapalene 0.1% cream is itself far more expensive per gram than the OTC 0.1% gel.

Isotretinoin: the cost of a full course

The US isotretinoin labels recommend 0.5 to 1 mg/kg/day in two divided doses for 15 to 20 weeks. For a 60 kg patient at 1 mg/kg/day, that is 30 mg twice daily, or 280 capsules of 30 mg over 20 weeks. The table prices that example using the 28 October 2026 NADAC for a 30 mg capsule.

Product (30 mg capsule)	NADAC per capsule	280 capsules (20 weeks)	210 capsules (15 weeks)
Claravis, Amnesteem, Zenatane	$2.01016	$562.84	$422.13
Isotretinoin (generic name)	$5.42775	$1,519.77	$1,139.83
Absorica	$38.23579	$10,706.02	$8,029.52

Claravis, Amnesteem and Zenatane are generic isotretinoin capsules sold under trade names, and NADAC classes them as generics. Absorica is a different formulation that can be taken with or without meals; its label says it is not substitutable with Absorica LD on a milligram basis. Lab tests and the iPLEDGE visits are extra. Our isotretinoin for acne guide covers results, relapse and side effects.

iPLEDGE: what the program requires

Every isotretinoin label carries a boxed warning: isotretinoin "can cause life-threatening birth defects and is contraindicated in pregnancy." Because of that risk, the FDA requires all isotretinoin to be supplied through a single restricted program, iPLEDGE, which began in 2005 and became a REMS in 2010. According to the label and the FDA:

• Prescribers must be certified, assess each patient's reproductive status, counsel patients, review pregnancy tests and report all pregnancies.
• Pharmacies must be certified, and can only dispense once the system confirms the requirements have been met.
• Patients who can become pregnant must enroll, follow the pregnancy testing and prevention rules, show they understand the risks before each prescription, and collect each prescription within 7 days of the pregnancy test.
• Patients who cannot become pregnant must enroll, must not share isotretinoin and must not donate blood.

On 9 February 2026 the FDA approved changes to reduce the burden: prescribers may now allow at-home pregnancy tests during and after treatment, the waiting period for repeat tests after a missed 7-day window was removed, and patients who cannot get pregnant no longer need monthly documentation of counseling. Pre-treatment pregnancy tests must still be done in a medical setting. The iPLEDGE contact center is 866-495-0654.

Why isotretinoin cannot legally be bought around iPLEDGE in the US

The FDA states that health care professionals and pharmacies "must be registered with iPLEDGE to be able to prescribe and dispense isotretinoin to patients", and that patients must also be enrolled to receive it. A pack posted from another country is not dispensed by an iPLEDGE-certified pharmacy, so it sits outside the only lawful US route. The FDA's personal importation page (next section) lists a product that "appears to present a serious risk to health" among the reasons it would refuse a personal import, and the label calls the risk of birth defects "extremely high" if pregnancy occurs during treatment.

There are medical reasons too. The label lists psychiatric effects, including depression and, rarely, suicidal thoughts, and reports intracranial hypertension (raised pressure in the skull) with isotretinoin, some cases involving tetracyclines, so it says to avoid using tetracyclines such as doxycycline and minocycline at the same time. It also requires a fasting lipid profile and liver tests before starting. Those checks are part of what you lose by skipping the program.

Spironolactone for hormonal acne: what the label does and does not say

Some prescribers use spironolactone off label for acne in women. Its US label (Aldactone, Pfizer) lists heart failure, hypertension, edema from cirrhosis or nephrotic syndrome, and primary hyperaldosteronism; acne is not among the approved uses. Whoever prescribes it, the safety information comes from that label:

• It is contraindicated with hyperkalemia, Addison's disease and use of eplerenone.
• It can cause hyperkalemia; the label says to check potassium within 1 week of starting or changing the dose and regularly after.
• It can cause gynecomastia, and the label notes animal findings that it may affect sex differentiation of a male fetus.

Generic spironolactone is cheap at the pharmacy level ($0.08328 per 50 mg tablet in October 2026), but it needs a prescriber who will monitor potassium.

Safety rules that apply whatever the price

A cheaper source does not change the label. The points patients most often miss:

• Tazarotene cream and gel are contraindicated in pregnancy; the label says retinoids may cause fetal harm.
• Clindamycin topical products are contraindicated in people with a history of regional enteritis, ulcerative colitis or antibiotic-associated colitis.
• Dapsone gel: methemoglobinemia leading to hospital admission has been reported; people with G6PD deficiency or congenital or idiopathic methemoglobinemia are more susceptible.
• Doxycycline and minocycline: tetracyclines used during tooth development (last half of pregnancy, infancy and childhood to age 8) may cause permanent tooth discoloration.
• Epiduo Forte is contraindicated in people with a history of hypersensitivity to benzoyl peroxide or any ingredient.

Practical ways to pay less

• Try the OTC options first for mild acne, and give adapalene the full time its label allows before deciding it has failed.
• Ask for the generic and the cheaper form. A cream is often cheaper per gram than a gel or pump of the same drug.
• Check the strength. A higher strength is not always more expensive, as the tretinoin figures show, and the reverse can also be true.
• Compare pharmacies and ask the cash price as well as the insured price.
• For isotretinoin, ask whether a lower-cost generic brand such as Claravis, Amnesteem or Zenatane can be dispensed; in October 2026 they cost pharmacies less than half of isotretinoin sold under the generic name.

Buying acne medicine from abroad: what the FDA says

The FDA's personal importation page is direct: "In most circumstances, it is illegal for individuals to import drugs or devices into the U.S. for personal use because these products purchased from other countries often have not been approved by the FDA for use and sale in the U.S." It says the FDA "recommends only obtaining medicines from legal sources in the U.S."

The same page says FDA staff "may consider a more permissive decision" in some situations, for example where the product is not for a serious condition and there is no known significant health risk, or, for a serious condition, where effective treatment is not available in the US, there is no promotion to US residents, the product does not represent an unreasonable risk, the consumer affirms in writing that it is for personal use, the quantity is generally not more than a three month supply, and the consumer gives the name of a US-licensed doctor or evidence that treatment began abroad. These are discretionary, not a right. Read the FDA personal importation page yourself and check your own situation before you order anything from outside the US.

Warning signs of an unsafe online pharmacy

The FDA's BeSafeRx campaign gives a simple test. A safe online pharmacy is licensed by a US state board of pharmacy (you can check with the FDA's state license locator), requires a prescription from a licensed health care provider, gives a physical address and a US telephone number, and has a licensed pharmacist available to answer questions. The FDA says if a pharmacy is not in the state database, do not use it.

The FDA's red flags include:

• selling prescription medicines without requiring a prescription;
• deep discounts or prices that seem too good to be true;
• unsolicited mail, email or spam offering cheap medicines;
• being located outside the US or stating that medicines ship from a foreign country;
• on arrival: broken or damaged packaging, misspellings, no expiry date or an expired product, or charges for a drug you never ordered.

Our longer checklist is in how to verify a legitimate online pharmacy.

What SafeRxPills sells for acne, and what it is not

Measured against the FDA test above, you should know what we are. SafeRxPills is run from Surat, Gujarat, India, and sells medicines made in India. Our own site states: "We are not licensed by the FDA." Our about page says SafeRxPills is operated by Actiza Pharmaceutical Pvt. Ltd., and our Acticycline listing names its maker as Actiza Pharma Pvt. Ltd., so our operator's name matches the listed maker of that product. We do not claim to be a US state-licensed pharmacy, our acne listings are not marked as requiring a prescription, and we are based outside the US. Those are points on the FDA's list, so read the import rules above and decide with that in mind.

Prices as of 28 October 2026, from our live product listings:

Product	What it contains	Smallest and largest pack	Per tube or unit, smallest to largest pack
Epiduo Gel (Galderma India)	Adapalene 0.1% / benzoyl peroxide 2.5%	1 tube $25.00; 6 tubes $105.00	$25.00 to $17.50
Adapen 15 g (Intas)	Adapalene gel	3 tubes $27.50; 12 tubes $95.00	$9.17 to $7.92
Persol AC 5% Gel (Wallace)	Benzoyl peroxide 5%	3 tubes $20.00; 12 tubes $72.50	$6.67 to $6.04
Erytop Gel (USV)	Clindamycin 1%	3 tubes $16.25; 12 tubes $53.75	$5.42 to $4.48
A Ret Gel 0.025% (Menarini India)	Tretinoin 0.025%	3 tubes $18.00; 24 tubes $100.00	$6.00 to $4.17
Acnedap 15 g (Cipla)	Dapsone 5% gel	1 tube $21.00; 6 tubes $85.00	$21.00 to $14.17
Aziderm Cream (Micro Labs)	Azelaic acid 15%	3 tubes $28.75; 12 tubes $103.75	$9.58 to $8.65
Acticycline 100 mg (Actiza)	Doxycycline 100 mg	100 capsules $30.00; 300 capsules $68.75	$0.30 to $0.23
Cynomycin 100 mg (Pfizer India)	Minocycline 100 mg	28 capsules $120.00; 84 capsules $212.50	$4.29 to $2.53

Be careful comparing these with NADAC. Our listings do not state the tube size for every product, and NADAC is a pharmacy's cost, not a patient's price. For the oral antibiotics the comparison is clear and not in our favor: US pharmacies paid $0.10794 for a doxycycline 100 mg capsule and $0.33466 for a minocycline 100 mg capsule, against our $0.30 to $0.23 and $4.29 to $2.53, so a US patient with a prescription may well pay less at a local pharmacy. We also list isotretinoin capsules. We do not link them here, and we do not suggest that anyone in the US use them as a way around iPLEDGE.

Questions to ask your prescriber or pharmacist

• Is my acne mild enough to try OTC adapalene or benzoyl peroxide first, and for how long?
• Is there a generic of what you are prescribing, and is the cream cheaper than the gel?
• Should I combine a retinoid with benzoyl peroxide, and in one product or two?
• If you prescribe doxycycline or minocycline, how long should I take it, and with what topical?
• Am I a candidate for isotretinoin, and what will iPLEDGE involve for me?
• If spironolactone is suggested, how often will my potassium be checked?
• Is any of this unsafe if I become pregnant?

Related guides

• Adapalene vs tretinoin: what the head to head trials show
• Buy tretinoin online: prices and what to check
• Topical antibiotics for acne: clindamycin gel
• Which prescription acne cream works best
• Doxycycline for acne: dose and duration
• Isotretinoin for acne: results, relapse and the pregnancy rules
• Azelaic acid cream for acne and rosacea

Sources

1. US Food and Drug Administration. Differin Gel (adapalene) 0.1%, approval letter for NDA 020380/S-010 (over-the-counter use), 8 July 2016; and Drugs@FDA via openFDA, NDA 020380, 020748, 021753, 022320, 207917 and 220736, accessed 28 October 2026.
2. US Food and Drug Administration. NDA 020380/S-010 cross-discipline review (advisory committee vote, April 2016).
3. Differin Gel 0.1% Drug Facts label, Galderma (DailyMed setid 0739d631-171b-42a8-bd55-0022b8df2d8a).
4. Differin Epiduo Drug Facts label, Galderma, May 2026 (DailyMed setid ae3f8cd9-9046-4b69-b80f-3e9d4468ba7f).
5. US Food and Drug Administration. OTC Monograph M006: Topical Acne Drug Products for Over-the-Counter Human Use (posted 23 November 2021), section M006.10.
6. Centers for Medicare and Medicaid Services. National Average Drug Acquisition Cost (NADAC), 2026 file, rows as of 28 October 2026; and Retail Price Survey page (medicaid.gov).
7. Claravis (isotretinoin capsules) US prescribing information, Teva, July 2026 (DailyMed setid a31fd109-d0fd-4ab9-ba98-a3d64333c18d): boxed warning, sections 1, 2.1 to 2.3, 5.2 to 5.4.
8. Absorica and Absorica LD US prescribing information, Sun Pharmaceutical Industries, August 2026 (DailyMed setid 3ef0cff8-19c1-4441-b780-fca6c7ee1615): sections 2.2 and 5.3.
9. US Food and Drug Administration. Questions and Answers on the iPLEDGE REMS (content current as of 16 June 2026), and iPLEDGE REMS page.
10. Aldactone (spironolactone) US prescribing information, Pfizer, November 2025 (DailyMed setid 0fed2822-3a03-4b64-9857-c682fcd462bc): sections 1, 4, 5.1, 5.4, 8.1.
11. Doxycycline hyclate US label (DailyMed setid 051654c7-8ba6-44f2-842c-72f515e9b32d) and Minocin (minocycline) US label, Melinta, September 2025 (setid e415c323-8219-464b-9e3e-72c5a796cdaa): indications and warnings.
12. Tazorac cream and gel US prescribing information, Almirall, November 2025 (setids 021744d1-a6d7-4ad6-99c2-7187c24e64c6 and 4e4e4b81-420e-4492-8a74-80b692a80057): sections 1 and 4.
13. Aczone (dapsone) gel 7.5% US prescribing information, Almirall, October 2025 (setid 22058b7d-a578-4eaa-a476-ac982337f02a); Cleocin T US label, Pfizer, November 2025 (setid 4a3901a4-194f-4a15-9c85-3d0982afcf31); Retin-A US label, Bausch Health (setid 9556d73d-c573-4e0a-9feb-764ce2d1107b); Epiduo Forte US label, Galderma (setid f4e5d381-098a-4c93-9ff0-002cae46daac).
14. Azelex cream US label (openFDA setid ebdfcaf7-b5d6-47e1-be87-ccaba4b97e75) and azelaic acid gel 15% US label, Glenmark (setid 0b5ab22e-c78a-4429-9a76-a4ba2d11fcde): indications.
15. US Food and Drug Administration. Personal Importation (fda.gov/industry/import-basics/personal-importation), accessed 28 October 2026.
16. US Food and Drug Administration. How to Buy Medicines Safely From an Online Pharmacy (content current as of 2 January 2025), and BeSafeRx podcast interview with CDR Lysette Deshields (fda.gov).
17. US Food and Drug Administration. Briefing document, joint Drug Safety and Risk Management and Dermatologic and Ophthalmic Drugs Advisory Committee meeting on the iPLEDGE REMS, March 2023 (fda.gov/media/166485): pharmacy authorization (RMA) process.
18. SafeRxPills product_variants table, prices as of 28 October 2026; saferxpills.com shipping and about pages, read 28 October 2026.

This guide is for information and does not replace advice from a doctor or pharmacist who knows your medical history. Do not start isotretinoin, spironolactone or an oral antibiotic without a prescriber.