Antibiotics Articles
Evidence-based articles about antibiotics from certified pharmacists
Norfloxacin 400 mg: Uses, Dosage, Side Effects and Why It Left US Pharmacies
Norfloxacin is an older fluoroquinolone antibiotic, sold as Noroxin in the US until 2015 and as Norflox in India. This guide covers the label doses by infection, how to take it, side effects and the boxed warning, interactions, trial results for cystitis and cirrhosis, and what the FDA and EMA decided.
Doxycycline Dosage by Indication: From 40 mg to 200 mg a Day
Doxycycline is dosed across a five fold range and the same capsule serves completely different purposes depending on indication. Verified regimens for chlamydia, doxy PEP, Lyme prophylaxis and treatment, malaria prophylaxis, anthrax, acne and rosacea, with paediatric and renal dosing and the interactions that reduce absorption.
Doxycycline vs Minocycline: Same Results, Different Risks
Doxycycline and minocycline produce comparable results in acne, so the choice is a safety trade off rather than an efficacy one. Cochrane found no evidence minocycline is superior and more severe adverse effects than doxycycline, including drug induced lupus at 8.8 cases per 100,000 person years. Full side by side on vestibular effects, pigmentation, photosensitivity, renal dosing and cost.
Amoxicillin and Clavulanate Dosage: Why Two 250 mg Tablets Are Not One 500 mg
A 625 mg co-amoxiclav tablet is 500 mg amoxicillin plus 125 mg clavulanate, and every common strength carries the same 125 mg of clavulanate. That is why two 375 mg tablets are not one 750 mg dose, and why the label forbids certain substitutions.
Azithromycin Dosage: Why a Five Day Course Keeps Working After You Stop
Azithromycin has a serum half life near 70 hours, so a five day course keeps working long after the last tablet. Labelled doses by infection, the trial data showing three and five day courses give comparable total exposure, and the QT warning that decides who should avoid it.
Nitrofurantoin for UTI: Dosing, and Why It Fails Above the Bladder
Nitrofurantoin concentrates in urine and barely reaches anything else, which makes it excellent for cystitis and useless for a kidney infection. Labelled dosing, why every dose needs food, and the pulmonary reaction that appears after six months of suppressive therapy.
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