Diabetes Articles
Evidence-based articles about diabetes from certified pharmacists
Metformin vs Glimepiride: How the Two Most Prescribed Oral Diabetes Tablets Differ
Metformin lowers hepatic glucose output and improves insulin sensitivity; glimepiride forces insulin release. That single mechanistic difference explains the hypoglycaemia rates, the weight effects and why the two are so often combined.
Metformin Side Effects: Trial Incidence Rates, GI Timing and B12 Monitoring
What the registration trials actually reported: diarrhoea in 53.2 percent on immediate-release metformin versus 9.6 percent on extended-release, vitamin B12 decline in 7 percent, and lactic acidosis at 0.03 cases per 1,000 patient-years.
Metformin Dosage Guide: Starting Doses, Titration Steps and Maximum Daily Limits
Exact metformin dosing from the approved label: 500 mg or 850 mg starting doses, weekly titration steps, the 2,550 mg immediate-release and 2,000 mg extended-release ceilings, and the eGFR thresholds that decide eligibility.
Showing 1-3 of 3 articles