Biltree 600mg

Biltree 600mg contains 600mg of praziquantel per tablet, the only drug the WHO Essential Medicines List specifies for all forms of schistosomiasis and the first-line treatment for most adult tapeworms. The standard adult dose for schistosomiasis is 40 milligrams per kilogram body weight as a single oral dose; for a 60 kg adult that is exactly four Biltree 600mg tablets, or expressed differently, one tablet covers 15 kg of body weight in the dosing arithmetic. Kachhela Medex Pvt. Ltd. manufactures Biltree 600mg at a WHO-GMP certified facility in India.

What praziquantel actually treats

Praziquantel is active against trematodes (flatworms or flukes) and cestodes (tapeworms). Specific indications include all five species of human-infecting Schistosoma (haematobium, mansoni, japonicum, intercalatum, mekongi), liver flukes (Clonorchis sinensis, Opisthorchis viverrini, Fasciola hepatica with caveats), the lung fluke Paragonimus westermani, and adult intestinal tapeworms (Taenia saginata, Taenia solium, Diphyllobothrium latum, Hymenolepis nana). For neurocysticercosis (Taenia solium larvae in the central nervous system), praziquantel is used at higher protocol doses with corticosteroid cover, typically under hospital supervision (PMID:36214445).

If your suspected parasite is a roundworm rather than a fluke or tapeworm, praziquantel is the wrong drug. For roundworm infections, you need a benzimidazole like Zentel 400mg (albendazole) or Mebex 100mg (mebendazole), or ivermectin via Ivercor 12mg. For tapeworm specifically with a single-tablet alternative, Niclosamide 500mg is the second-line option used when praziquantel is unavailable or contraindicated.

Praziquantel dosing in 2025: the 40 vs 80 mg/kg question

The WHO-recommended standard dose is 40 mg/kg single dose for adult schistosomiasis. A 2025 phase 2 randomised trial in Ugandan preschool-aged children directly compared 40 mg/kg versus 80 mg/kg single doses, examining cure rate, egg reduction, and tolerability (PMID:40412398). A 2017 meta-analysis of 18 studies covering 6,761 children at the 40 mg/kg dose found pooled cure rates of 87 percent for Schistosoma haematobium and 67 percent for Schistosoma mansoni, with mild adverse events in roughly 31 percent (mostly transient abdominal pain, headache, and dizziness) (PMID:28126024).

For adult tapeworm treatment, the dose drops to 10 to 25 mg/kg single dose, depending on the species. Hymenolepis nana (the dwarf tapeworm) requires a higher 25 mg/kg dose because of its different lifecycle inside the host. Always confirm species identification before dosing, since adult intestinal taeniasis and larval neurocysticercosis use very different praziquantel regimens and post-treatment monitoring.

How to take Biltree 600mg

Swallow Biltree 600mg tablets whole with water during or immediately after a meal. Praziquantel has a bitter taste, so do not chew or split tablets unless you must. Food increases bioavailability by approximately 100 percent compared with fasted administration, which is why the with-meal instruction is universal. For doses requiring more than 4 tablets, take the total in 2 to 3 portions spaced 4 to 6 hours apart on the same day to reduce peak-related nausea, while still completing the full daily dose.

Avoid grapefruit juice within 24 hours of dosing; it inhibits CYP3A4 and can sharply raise praziquantel levels. Do not drive or operate machinery for at least 24 hours after dosing because of common transient dizziness. Effects on the parasite begin within hours: praziquantel induces calcium influx and tetanic muscle contraction in the worm, exposing parasite antigens to host immune attack.

Side effects, contraindications, and special populations

Most users tolerate praziquantel well at the standard 40 mg/kg single dose. Common adverse events, occurring in 5 to 30 percent of users depending on parasite burden and species, are abdominal pain, nausea, headache, dizziness, and drowsiness. These are largely attributable to the immune response to dying parasites rather than to the drug itself, and they peak in the 4 to 24 hours after dosing.

A 2024 single-blinded controlled trial in pregnant women in Gabon found praziquantel acceptably safe during pregnancy for treating Schistosoma haematobium, supporting WHO updated guidance allowing treatment during the second and third trimesters (PMID:39368731). A 2003 review of non-clinical toxicity and pharmacokinetics for the benzimidazoles and praziquantel summarises the older animal and toxicology data still cited in modern dosing decisions (PMID:12745134).

Absolute contraindications: ocular cysticercosis (use of praziquantel can cause irreversible eye damage as parasites die in the eye) and known hypersensitivity. Use caution in severe hepatic impairment (dose adjustment may be needed) and in patients on rifampicin, which is a strong CYP3A4 inducer and can lower praziquantel levels by up to 85 percent, requiring alternative dosing. For neurocysticercosis specifically, do not dose without prior brain imaging and corticosteroid cover; rapid parasite death inside the CNS can trigger severe inflammation.

Why Biltree 600mg specifically

The 600mg tablet strength is the global standard for praziquantel (also marketed internationally as Biltricide, Distocide, and Cesol at the same 600mg unit). The 600mg dose divides cleanly into the 15 kg-per-tablet schistosomiasis schedule, making weight-band dosing straightforward without splitting tablets. Biltree 600mg from Kachhela Medex offers the same active ingredient at a fraction of the branded price, with WHO-GMP manufacturing standards. For background on antiparasitic drug classes and how praziquantel fits in, see our antiparasitic medicine guide and the niclosamide antiparasitic guide for the tapeworm alternative.

Order Biltree 600mg to USA, UK, Australia and Canada

SafeRxPills ships Biltree 600mg in plain, unmarked packaging to the United States, United Kingdom, Australia and Canada within 7 to 14 business days. Every order ships from a WHO-GMP certified Kachhela Medex batch with tracking from dispatch to delivery. If you are uncertain whether your symptoms point to schistosomiasis, tapeworm, or roundworm, please get a confirmed parasitological diagnosis before ordering; praziquantel is highly effective for flukes and tapeworms but does nothing for roundworms.