Ofloxacin Eye Drops: Dosage, Side Effects, Eye vs Ear Use and US Cost
Lokesh Maurya

Ofloxacin Eye Drops: Dosage, Side Effects, Eye vs Ear Use and US Cost - pharmacy guide
In this article (26 sections)
Ofloxacin eye drops (ofloxacin ophthalmic solution 0.3%, brand name Ocuflox in the US) are a prescription fluoroquinolone antibiotic for two eye infections: bacterial conjunctivitis and bacterial corneal ulcers. This guide sets out what the US label says about each use, the exact dosing schedules, how to put the drops in, side effects, warnings, use in pregnancy and in children, how ofloxacin compares with the other fluoroquinolone eye drops, the difference between ofloxacin eye drops and ofloxacin ear drops, and what a bottle costs US pharmacies.
Every dose, warning and number below comes from the current US labels on DailyMed, Drugs@FDA and the CMS NADAC price survey, all opened on 2 November 2026 (sources at the end of this page). Your prescriber may give a different schedule; follow the prescription.
Ofloxacin eye drops at a glance
| Item | What the US label says |
|---|---|
| Active ingredient | Ofloxacin 0.3% (3 mg per mL), a fluorinated quinolone antibiotic |
| Preservative | Benzalkonium chloride 0.005% (Ocuflox) |
| Labeled uses | Bacterial conjunctivitis and bacterial corneal ulcers caused by susceptible strains of listed bacteria |
| Conjunctivitis dose | Days 1 and 2: one to two drops every two to four hours; days 3 through 7: one to two drops four times daily |
| Corneal ulcer dose | Far more frequent, starting every 30 minutes while awake (see below) |
| Contraindication | History of hypersensitivity to ofloxacin, to other quinolones, or to any component |
| Children | Safety and effectiveness below the age of one year have not been established |
| Route | Eye only. "NOT FOR INJECTION." |
| US bottle sizes | 5 mL (Ocuflox); 5 mL and 10 mL (generics such as Apotex) |
| Status | Prescription only ("Rx only") |
What ofloxacin eye drops treat
The Ocuflox label lists two indications, each tied to named bacteria:
- Bacterial conjunctivitis caused by Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Enterobacter cloacae, Haemophilus influenzae, Proteus mirabilis and Pseudomonas aeruginosa.
- Bacterial corneal ulcers caused by Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Pseudomonas aeruginosa, Serratia marcescens (studied in fewer than 10 infections) and the anaerobe Propionibacterium acnes.
Ofloxacin works by blocking DNA gyrase, an enzyme bacteria need to copy and repair their DNA. The label notes cross-resistance between ofloxacin and other fluoroquinolones, but generally none with beta-lactams or aminoglycosides. That matters if a first fluoroquinolone drop has failed: switching to another fluoroquinolone may not help, which is one reason a culture or an eye examination comes first. It does nothing against viruses, fungi or allergy.
Do you need antibiotic eye drops for pink eye?
Often not. Pink eye (conjunctivitis) can be viral, bacterial or allergic, and an antibiotic drop only acts on bacteria. Our antibiotic eye drops guide covers when pink eye is likely to need an antibiotic, what the 2023 Cochrane review found, and how ofloxacin sits among all the antibiotic classes. This page stays with ofloxacin itself.
Ofloxacin eye drops dosage for bacterial conjunctivitis
The Ocuflox label and the generic labels give the same schedule:
| Days | Dose in the affected eye(s) |
|---|---|
| Days 1 and 2 | One to two drops every two to four hours |
| Days 3 through 7 | One to two drops four times daily |
That is a 7 day course. The label does not set a maximum number of daily doses on days 1 and 2 beyond the two to four hour interval, and it does not say to dose through the night for conjunctivitis. Finish the course your prescriber sets, even if the eye looks better after a day or two.
Ofloxacin dosage for a bacterial corneal ulcer
A corneal ulcer is an infection of the clear front surface of the eye and can threaten sight. The label schedule is much more intensive, and it is meant to be run under an eye doctor's care:
| Days | Dose in the affected eye |
|---|---|
| Days 1 and 2 | One to two drops every 30 minutes while awake. Wake at about four and six hours after going to bed and put in one to two drops. |
| Days 3 through 7 to 9 | One to two drops hourly while awake |
| Days 7 to 9 through the end of treatment | One to two drops four times daily |
In the label's corneal ulcer trial, the median time to clinical success was 11 days on ofloxacin. The end of treatment is set by the eye doctor based on healing, not by a fixed day count.
How to put in ofloxacin eye drops
- Wash your hands.
- Tilt your head back, gently pull the lower lid down to make a small pocket, and squeeze one drop into it.
- Close the eye gently for a moment. If your dose is two drops, put the second one in after the first has settled.
- Do not let the tip touch the eye, lids, fingers or anything else. The label says to avoid contaminating the applicator tip with material from the eye, fingers or other source.
- Put the cap back on straight away.
- If you use another eye drop, leave a few minutes between them so the second does not wash out the first (our advice; the label does not cover this).
- Store the bottle at 15°C to 25°C (59°F to 77°F), as the Ocuflox label says.
The drops are for the surface of the eye only. The label warns that the solution should not be injected under the conjunctiva, nor put directly into the anterior chamber of the eye.
What the label trials showed
Two randomized, double-masked, multicenter trials sit on the Ocuflox label.
| Trial | Outcome | Ofloxacin 0.3% | Comparator |
|---|---|---|---|
| Conjunctivitis, positive cultures | Clinical improvement after 2 days | 86% (54 of 63) | Vehicle 72% (48 of 67) |
| Conjunctivitis, positive cultures | Pathogens eradicated after 2 days | 65% (41 of 63) | Vehicle 25% (17 of 67) |
| Corneal ulcer, 140 people with positive cultures | Clinical success (healed surface, no spread, two visits in a row) | 82% (61 of 74) | Fortified tobramycin 1.5% plus cefazolin 10%: 80% (53 of 66) |
| Corneal ulcer | Median time to success | 11 days | 10 days |
Two points stand out. Most people on the vehicle drop (72%) also improved by day 2 in the conjunctivitis trial. In corneal ulcers, ofloxacin alone did about as well as a fortified two-drug combination of tobramycin 1.5% and cefazolin 10% drops. The label adds that eradication of bacteria does not always match the clinical result.
How much ofloxacin reaches the blood
Very little. In the label's study of 30 healthy women dosing four times a day for about ten and a half days, mean blood levels ranged from 0.4 to 1.9 ng/mL, and peak levels after ten days were more than 1000 times lower than after standard oral doses of ofloxacin. Tear levels four hours after a dose averaged 9.2 mcg/g. The eye drop label carries no boxed warning. For the fluoroquinolone tablet warnings, see our norfloxacin guide, and the Oflox 200mg tablet page. Tablets are a different product; do not take them for an eye infection unless a doctor tells you to.
Ofloxacin eye drops side effects
The label says the most frequently reported drug-related reaction was transient burning or discomfort in the eye. Other reported reactions:
- stinging, redness and itching
- chemical conjunctivitis or keratitis (irritation of the eye surface)
- swelling of the eye, the skin around it or the face
- a feeling of something in the eye, sensitivity to light, blurred vision, tearing, dryness and eye pain
- rare reports of dizziness and nausea
The US ophthalmic label gives no percentage for any of these, so any figure you see quoted for ofloxacin eye drops side effects is not from the US label. The ear drop label does give rates, shown further down. Blurred vision straight after a drop usually passes; wait until you can see clearly before driving.
Allergic reactions: when to stop the drops
The label warns that rare anaphylactic reactions and fatal hypersensitivity reactions, some after the first dose, have been reported in patients taking quinolones by mouth or injection, including ofloxacin. Some came with collapse, loss of consciousness, swelling of the throat or face, airway blockage, breathlessness, hives and itching. A rare case of Stevens-Johnson syndrome that progressed to toxic epidermal necrolysis has been reported in a patient using ofloxacin eye drops.
The label's instruction to patients: discontinue use immediately and contact your physician at the first sign of a rash or allergic reaction. Serious reactions may need emergency treatment. If you have ever reacted to ciprofloxacin, levofloxacin, moxifloxacin or any other quinolone, ofloxacin drops are contraindicated.
Warnings: long use, superinfection and not for injection
- Prolonged use. As with other anti-infectives, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. If a superinfection occurs, the label says to stop and use another treatment.
- Examination. Whenever clinical judgment dictates, the label says the eye should be examined with magnification, such as a slit lamp, and with fluorescein staining where appropriate.
- Not for injection. Not to be injected under the conjunctiva or into the anterior chamber.
- Joints in young animals. Quinolones taken by mouth have caused joint damage in young animals. The label says ofloxacin drops placed in the eyes of young animals did not, and that there is no evidence the eye drop form affects weight-bearing joints.
Keeping a bottle to treat the next red eye is a poor idea: a red eye may not be bacterial at all, and repeated courses without a diagnosis feed antibiotic resistance (our advice).
Contact lenses and ofloxacin drops
The US Ocuflox and generic ofloxacin eye labels give no contact lens instruction at all. Other US fluoroquinolone eye labels do: the Vigamox label advises patients not to wear contact lenses if they have signs or symptoms of bacterial conjunctivitis, the besifloxacin label says not to wear them during the course of therapy, and the ciprofloxacin eye drop label says to remove contact lenses before using. Ocuflox also contains the preservative benzalkonium chloride. Our advice: the sensible course is to leave lenses out until the infection has cleared and your prescriber says they can go back in, and to treat a red, painful eye in a lens wearer as urgent.
Pregnancy and breastfeeding
Pregnancy. In animal studies, very high oral doses (810 mg/kg/day in rats, equal to 9000 times the maximum daily eye dose, and 160 mg/kg/day in rabbits) were toxic to embryos: fetal weight fell in rats and fetal deaths rose in rabbits, without birth defects. There are no adequate and well-controlled studies in pregnant women. The label says ofloxacin eye drops should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Breastfeeding. A single 200 mg oral dose produced milk levels similar to blood levels. It is not known whether ofloxacin passes into milk after eye use. Because of the potential for serious adverse reactions in nursing infants, the label says a decision should be made whether to stop nursing or stop the drug, taking into account how important the drug is to the mother.
Children and older adults
The label says safety and effectiveness in infants below the age of one year have not been established. That differs from ciprofloxacin and moxifloxacin eye drops, whose US labels say safety and effectiveness have been established in all ages, including newborns. A baby with red, sticky eyes needs to be seen by a doctor, who will choose the drop.
For older adults, the label reports no overall differences in safety or effectiveness compared with younger patients.
Drug interactions
No interaction studies were done with the eye drops. The label notes that quinolones taken by mouth or injection have raised theophylline levels, interfered with the breakdown of caffeine, increased the effect of warfarin, and been linked to short rises in creatinine with cyclosporine. Given the very low blood levels after eye use, these are mainly reasons to tell your prescriber what else you take, especially warfarin.
Ofloxacin eye drops vs ear drops: two separate US labels
Both products contain ofloxacin 0.3% (3 mg per mL), but in the US they are separate products with separate labels, separate approvals and different directions.
| Feature | Ofloxacin ophthalmic solution 0.3% (eye) | Ofloxacin otic solution 0.3% (ear) |
|---|---|---|
| Labeled uses | Bacterial conjunctivitis; bacterial corneal ulcers | Otitis externa (6 months and older); acute otitis media with ear tubes (1 to 12 years); chronic suppurative otitis media with a perforated eardrum (12 years and older) |
| Route warning | "NOT FOR INJECTION." The label does not mention the ear. | "NOT FOR OPHTHALMIC USE." and "NOT FOR INJECTION." |
| Benzalkonium chloride | 0.005% (Ocuflox) | 0.0025% (Apotex) |
| Typical dose | One to two drops, several times a day | Five or ten drops into the ear, once or twice daily |
| Youngest labeled age | Not established below one year | 6 months for otitis externa |
| Storage | 15°C to 25°C (Ocuflox) | 20°C to 25°C, protect from light (Apotex) |
| Original US approval | Ocuflox, NDA 019921, 30 July 1993 | Floxin Otic, NDA 020799, 16 December 1997 (brand now discontinued; generics marketed) |
The plain rule from the labels: the ear product says it is not for use in the eye, and the eye product carries no directions for the ear. Use each one only where its label and your prescriber say.
Ofloxacin otic: dose and side effects on the ear label
The ear label tells you to warm the bottle in your hand for one or two minutes (a cold solution can cause dizziness), lie with the affected ear up, put the drops in and stay in that position for five minutes. For middle ear infections, the tragus (the small flap in front of the ear canal) is pumped 4 times to push the drops through.
| Condition (ear label) | Age | Dose |
|---|---|---|
| Otitis externa (swimmer's ear) | 6 months to 13 years | Five drops (0.25 mL) once daily for seven days |
| Otitis externa | 13 years and older | Ten drops (0.5 mL) once daily for seven days |
| Acute otitis media with ear tubes | 1 to 12 years | Five drops twice daily for ten days |
| Chronic suppurative otitis media, perforated eardrum | 12 years and older | Ten drops twice daily for fourteen days |
Unlike the eye label, the ear label gives side effect rates. In 656 people with ear tubes or a perforated eardrum treated twice daily:
| Treatment related adverse event | Incidence (N=656) |
|---|---|
| Taste perversion | 7% |
| Earache | 1% |
| Pruritus (itching) | 1% |
| Paraesthesia | 1% |
| Rash | 1% |
| Dizziness | 1% |
In the once-daily otitis externa trials, application site reaction was reported in 16.8% of 310 people in studies 016/017; the label says the rate was similar for the active comparator and probably reflects specific questioning. The ear label also says that if the infection has not improved after one week, cultures should be taken, and that discharge persisting after a full course, or two or more episodes within six months, needs further evaluation.
Can you use ofloxacin eye drops in the ear?
The US eye label does not list any ear use and gives no ear dose, so using the eye product in the ear would be off-label, and we do not advise it. The ear product has a direct label statement the other way: "NOT FOR OPHTHALMIC USE." Do not put ofloxacin ear drops in the eye.
Some products sold outside the US are packed as combined "eye/ear drops". Our Oflox Eye Drop page notes that some Indian pharmacy listings describe the Indian Oflox as eye/ear drops while another says eye use only. Whatever the pack says, ear infections and eye infections need their own diagnosis, and the ear dosing above (warming, five or ten drops, tragus pumping) comes from the US otic label, not the eye label. Ask the prescriber which product to use and where.
Ofloxacin vs other fluoroquinolone eye drops
All five US fluoroquinolone eye drops below treat bacterial conjunctivitis; ofloxacin and ciprofloxacin are the two also labeled for corneal ulcers. The trials on each label used different endpoints and timepoints, so their percentages cannot be compared head to head.
| Drop (US label) | Labeled uses | Conjunctivitis dose | Youngest labeled age | Bottle |
|---|---|---|---|---|
| Ofloxacin 0.3% (Ocuflox) | Conjunctivitis, corneal ulcer | 1 to 2 drops every 2 to 4 hours days 1 and 2, then 4 times daily days 3 to 7 | Not established below 1 year | 5 mL |
| Ciprofloxacin 0.3% | Conjunctivitis, corneal ulcer | 1 or 2 drops every 2 hours while awake for 2 days, then every 4 hours while awake for 5 days | All ages | 2.5, 5 or 10 mL |
| Moxifloxacin 0.5% (Vigamox) | Conjunctivitis | 1 drop 3 times a day for 7 days | All ages | 3 mL |
| Gatifloxacin 0.5% (Zymaxid) | Conjunctivitis | Day 1: 1 drop every 2 hours while awake, up to 8 times; days 2 to 7: 1 drop 2 to 4 times daily | 1 year | 2.5 mL |
| Besifloxacin 0.6% suspension | Conjunctivitis | Shake once; 1 drop 3 times a day, 4 to 12 hours apart, for 7 days | 1 year | 5 mL |
Other label differences worth knowing:
- Contraindications. Ofloxacin, moxifloxacin and gatifloxacin are contraindicated with a history of hypersensitivity to other quinolones. The besifloxacin label lists no contraindications. The ciprofloxacin label says hypersensitivity to other quinolones "may also contraindicate" its use.
- Corneal deposits. In ciprofloxacin corneal ulcer studies, a white crystalline precipitate formed in the ulcer in 35 of 210 patients (16.6%); the label says it did not stop treatment or affect the outcome. The ofloxacin label reports no such deposit.
- Dosing burden. Moxifloxacin and besifloxacin are three times a day from the start; ofloxacin starts every two to four hours and ciprofloxacin every two hours while awake.
- Cost. Generic ofloxacin, ciprofloxacin and moxifloxacin cost US pharmacies far less than gatifloxacin or besifloxacin (see the cost section).
We also stock besifloxacin as Besix Eye Drops. For the full class picture, including tobramycin, polymyxin B with trimethoprim and azithromycin, see the antibiotic eye drops guide.
Oflox vs Oflox-D: when a steroid combination is not appropriate
Oflox and Oflox-D are Indian brands made by Cipla. Our product data describes them as follows:
| Product | Composition (our product listing) | Maker | Bottle size |
|---|---|---|---|
| Oflox Eye Drop | Ofloxacin 0.3% (3 mg per mL) | Cipla Limited | 5 mL on the Indian listings our product page cites |
| Oflox-D Eye Drop | Ofloxacin 0.3% with dexamethasone 0.1%, a corticosteroid | Cipla Limited | Not stated in our listing; check the carton |
Oflox-D is not a stronger Oflox. It adds a steroid, which damps inflammation but also damps the eye's defence against infection. Drugs@FDA lists no ofloxacin product with a second active ingredient, so there is no US label for an ofloxacin and dexamethasone eye drop. The closest US comparison is tobramycin with dexamethasone ophthalmic suspension, and its label sets out when this kind of drop must not be used:
- Contraindicated in epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, varicella and many other viral diseases of the cornea and conjunctiva; mycobacterial infection of the eye; fungal diseases of eye structures; and hypersensitivity to a component.
- Prolonged steroid use may result in glaucoma with optic nerve damage, defects in vision, and posterior subcapsular cataract. Eye pressure should be routinely monitored.
- In acute purulent (pus-forming) infections, steroids may mask infection or enhance existing infection.
- In diseases that thin the cornea or sclera, perforations have occurred with topical steroids.
- Fungal infection of the cornea should be considered after long-term steroid use.
- Not more than 20 mL should be prescribed initially, and the prescription should not be refilled without further evaluation.
- Contact lenses should not be worn during use; safety and effectiveness below the age of 2 years have not been established.
Because a viral or fungal eye infection can look like a bacterial one, our advice is that a steroid and antibiotic drop belongs in the hands of a clinician who has examined the eye, ideally with a slit lamp. If you only have a sticky red eye, a steroid combination is not the drop to reach for.
Approval history and US status
- Ocuflox (Allergan, NDA 019921) was approved on 30 July 1993 and is listed in Drugs@FDA as a prescription product and the reference listed drug.
- Drugs@FDA lists ten ofloxacin ophthalmic applications with prescription status (Ocuflox plus nine generic ANDAs, including Bausch & Lomb, Apotex, Sentiss and FDC) and five discontinued ones.
- Floxin Otic (Daiichi, NDA 020799), approved on 16 December 1997, is discontinued; seven generic ofloxacin otic ANDAs have prescription status.
- Ofloxacin tablets (Floxin) and injection are discontinued in Drugs@FDA; generic tablets remain.
No ofloxacin eye or ear product is sold over the counter in the US.
What ofloxacin eye drops cost in the US
The CMS NADAC survey records what US retail pharmacies pay for drugs. It is an acquisition cost, not the price at the counter, which includes the pharmacy's dispensing fee and margin. Rates below took effect on 21 October 2026 and are the latest in the file as of 28 October 2026 (Vigamox: rate effective 17 June 2026, still the latest in the file).
| Product | Bottle | NADAC per mL | Per bottle |
|---|---|---|---|
| Ofloxacin 0.3% eye drops (generic) | 5 mL | $1.22968 | $6.15 |
| Ofloxacin 0.3% eye drops (generic) | 10 mL | $1.10143 | $11.01 |
| Ofloxacin 0.3% ear drops (generic) | 5 mL | $1.17380 | $5.87 |
| Ofloxacin 0.3% ear drops (generic) | 10 mL | $0.99403 | $9.94 |
Bottle size for each rate was matched through the Apotex NDCs listed on its eye and ear labels (60505-0560-0 for 5 mL eye, 60505-0560-1 for 10 mL eye, 60505-0363-1 and 60505-0363-2 for the 5 and 10 mL ear bottles). NADAC has no row for the Ocuflox brand.
| Fluoroquinolone eye drop | Type | NADAC per mL | US label bottle | Per bottle |
|---|---|---|---|---|
| Ofloxacin 0.3% | Generic | $1.22968 | 5 mL | $6.15 |
| Ciprofloxacin 0.3% | Generic | $1.47777 | 5 mL | $7.39 |
| Moxifloxacin 0.5% | Generic | $1.66499 | 3 mL | $4.99 |
| Gatifloxacin 0.5% | Generic | $9.46564 | 2.5 mL | $23.66 |
| Vigamox (moxifloxacin) | Brand | $31.80800 | 3 mL | $95.42 |
| Besifloxacin 0.6% | Generic | $33.67760 | 5 mL | $168.39 |
| Besivance (besifloxacin) | Brand | $44.10026 | 5 mL | $220.50 |
Rates are for the bottle size shown (the 5 mL rate for ciprofloxacin; its 2.5 mL bottles cost US pharmacies $2.90163 per mL and its 10 mL bottles $0.87407). Per bottle is the per mL rate times that bottle size. The price you pay at a US pharmacy will be higher than NADAC, and depends on your insurance.
Our Oflox and Oflox-D prices
Prices from our product listings as of 2 November 2026, before shipping. We sell packs of bottles, not single bottles, for these two products.
| Product | Pack | Price | Per bottle |
|---|---|---|---|
| Oflox Eye Drop (ofloxacin 0.3%) | 3 bottles | $5.00 | $1.67 |
| Oflox Eye Drop | 6 bottles | $9.38 | $1.56 |
| Oflox Eye Drop | 12 bottles | $18.13 | $1.51 |
| Oflox-D Eye Drop (ofloxacin with dexamethasone) | 3 bottles | $10.00 | $3.33 |
| Oflox-D Eye Drop | 6 bottles | $16.00 | $2.67 |
| Oflox-D Eye Drop | 12 bottles | $28.00 | $2.33 |
Our shipping page lists standard registered shipping at a $25 flat rate, free on orders of $149 or more, with delivery in 7 to 14 business days to the US. So the smallest Oflox order costs $30.00 delivered, against about $6.15 that a US pharmacy pays for one 5 mL generic bottle. An eye infection needs treatment today, and two weeks is too long to wait. For one infection, a US prescription filled locally is faster and usually cheaper. A multi-bottle pack is also more than any labeled course; please do not keep spare bottles to treat future red eyes yourself.
Importing eye drops into the US
The Indian Oflox and Oflox-D packs are not FDA approved products. The FDA's personal importation page says: "In most circumstances, it is illegal for individuals to import drugs or devices into the U.S. for personal use" and "If a drug is approved for use in another country but is an unapproved new drug in the U.S. it is illegal to import." The same page describes limited situations in which FDA staff may make a more permissive decision. Check your own situation before ordering. Our guide to eye drop recalls and checking your bottle explains what to look at when a bottle arrives, and the prescription eye drops guide maps the other eye drop classes.
When to see a doctor about an eye infection
- Eye pain, reduced or blurred vision that does not clear with blinking, strong sensitivity to light, or a white spot on the clear front of the eye: these can be signs of a corneal ulcer and need same-day eye care.
- Any red, painful eye in a contact lens wearer.
- A baby under one year: the ofloxacin eye label has not established safety or effectiveness at this age.
- A rash, hives, swelling of the face or throat, or trouble breathing after a dose: stop the drops and get emergency help.
- No improvement, or worsening, on treatment: the label warns of overgrowth of nonsusceptible organisms, including fungi, and says to stop and switch treatment if a superinfection occurs.
- Ear pain or discharge: that is a matter for the ear label and an ear examination, not for eye drops.
Sources
- OCUFLOX (ofloxacin ophthalmic solution) 0.3%, US prescribing information, AbbVie/Allergan, revised 06/2024. DailyMed
- Ofloxacin ophthalmic solution USP 0.3%, Apotex Corp., US prescribing information. DailyMed
- Ofloxacin Otic Solution 0.3%, Apotex Corp., US prescribing information. DailyMed
- VIGAMOX (moxifloxacin ophthalmic solution) 0.5%, US prescribing information. DailyMed
- Ciprofloxacin ophthalmic solution 0.3%, Advagen, US prescribing information. DailyMed
- ZYMAXID (gatifloxacin ophthalmic solution) 0.5%, US prescribing information. DailyMed
- Besifloxacin ophthalmic suspension 0.6%, US prescribing information. DailyMed
- Tobramycin and dexamethasone ophthalmic suspension, Sandoz, US prescribing information, revised 10/2024. DailyMed
- US Food and Drug Administration, Drugs@FDA via openFDA: Ocuflox NDA 019921, Floxin Otic NDA 020799 and ofloxacin ANDAs, queried 2 November 2026. Drugs@FDA
- Centers for Medicare and Medicaid Services, National Average Drug Acquisition Cost (NADAC) 2026, file as of 28 October 2026. data.medicaid.gov
- US Food and Drug Administration, Personal Importation. FDA
This page is for information and is not medical advice. Ofloxacin eye and ear drops are prescription medicines; a clinician should confirm a bacterial infection and set your treatment.
Related Topics:
?Frequently Asked Questions
What are ofloxacin eye drops used for?
Ofloxacin ophthalmic solution 0.3% (Ocuflox and generics) is labeled in the US for two infections caused by susceptible bacteria: bacterial conjunctivitis and bacterial corneal ulcers. It does not treat viral, fungal or allergic eye problems.
What is the ofloxacin eye drops dosage for pink eye?
For bacterial conjunctivitis the US label says one to two drops in the affected eye(s) every two to four hours on days 1 and 2, then one to two drops four times daily on days 3 through 7. Follow your prescriber's directions if they differ.
How often do you use ofloxacin drops for a corneal ulcer?
Much more often. On days 1 and 2 the label says one to two drops every 30 minutes while awake, plus a dose about four and six hours after going to bed. From day 3 to day 7 to 9 it is hourly while awake, then four times daily until treatment ends. A corneal ulcer needs an eye doctor to diagnose and follow it.
What are the side effects of ofloxacin eye drops?
The US label says the most frequently reported reaction was transient burning or discomfort in the eye. Others include stinging, redness, itching, eye surface irritation, swelling around the eye or face, a feeling of something in the eye, light sensitivity, blurred vision, tearing, dryness and eye pain, with rare dizziness and nausea. The eye label gives no percentages.
Can ofloxacin eye drops cause an allergic reaction?
Yes. The drops are contraindicated if you have had hypersensitivity to ofloxacin or any other quinolone. A rare case of Stevens-Johnson syndrome progressing to toxic epidermal necrolysis has been reported with the eye drops. The label says to stop at the first sign of a rash or allergic reaction and contact your doctor; a severe reaction needs emergency care.
Can I use ofloxacin eye drops in my ear?
The US eye label lists no ear use and gives no ear dose, so that would be off-label, and we do not advise it. US ofloxacin ear drops are a separate product (ofloxacin otic solution 0.3%) with their own label, doses and age limits. Ask your prescriber which product to use.
Can ofloxacin ear drops be used in the eye?
No. The US ofloxacin otic solution label states "NOT FOR OPHTHALMIC USE." Use the ophthalmic (eye) product for eye infections.
Are ofloxacin eye drops safe in pregnancy and for children?
The US label says to use them in pregnancy only if the potential benefit justifies the potential risk to the fetus, since there are no adequate studies in pregnant women. Safety and effectiveness in infants below one year have not been established. Ciprofloxacin and moxifloxacin eye drops are labeled for all ages, including newborns.
Is ofloxacin better than moxifloxacin or ciprofloxacin eye drops?
The labels do not compare them head to head. Ofloxacin and ciprofloxacin are labeled for conjunctivitis and corneal ulcers; moxifloxacin, gatifloxacin and besifloxacin for conjunctivitis only. Moxifloxacin is one drop three times a day, while ofloxacin starts every two to four hours. In 5 mL bottles (3 mL for moxifloxacin), generic ofloxacin, ciprofloxacin and moxifloxacin cost US pharmacies under $1.70 per mL (NADAC, October 2026); small 2.5 mL ciprofloxacin bottles cost more per mL.
What is the difference between Oflox and Oflox-D eye drops?
Oflox contains ofloxacin 0.3% alone. Oflox-D, as listed on our site, adds the corticosteroid dexamethasone 0.1%. Comparable US steroid and antibiotic drops are contraindicated in viral infections of the cornea and conjunctiva such as herpes simplex keratitis, and in fungal and mycobacterial eye infections, and long use can raise eye pressure and cause cataract. Use a steroid combination only if an eye doctor prescribes it.
How much do ofloxacin eye drops cost?
NADAC, the US survey of pharmacy acquisition cost, puts generic ofloxacin 0.3% eye drops at $1.22968 per mL for 5 mL bottles (about $6.15 a bottle) and $1.10143 per mL for 10 mL bottles, effective 21 October 2026. Counter prices are higher. Our Oflox Eye Drop costs $5.00 for 3 bottles as of 2 November 2026, plus $25 shipping on orders under $149.
Lokesh Maurya
Pharmacist, Content, B.Pharm, M.Pharm, Rajiv Gandhi University
Pharmacist writing on antiparasitic, ophthalmic and dermatological generics. Focuses on what the regulatory labelling and published evidence actually support.
Comments (0)
Leave a Comment
No comments yet. Be the first to share your thoughts!
Related Articles



